General Information of the Compound
Compound ID
CP0360938
Compound Name
(8R,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13,14-trimethyl-17-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-1,2,6,7,8,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-3-one
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Structure
Formula
C30H38N2O4S
Molecular Weight
522.711
Canonical SMILES
Cn1c(SCC(=O)[C@@]2(O)CC[C@@]3(C)[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]23C)nc2ccccc12
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InChI
InChI=1S/C30H38N2O4S/c1-27-12-11-19(33)15-18(27)9-10-20-25(27)23(34)16-29(3)28(20,2)13-14-30(29,36)24(35)17-37-26-31-21-7-5-6-8-22(21)32(26)4/h5-8,15,20,23,25,34,36H,9-14,16-17H2,1-4H3/t20-,23+,25-,27+,28+,29+,30+/m1/s1
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InChIKey
NEPZSVKZUQUWAH-GVRKOPHQSA-N
Physicochemical Property
logP
4.8584
Rotatable Bonds
4
Heavy Atom Count
37
Polar Areas
92.42
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 70696161
ChEMBL ID
CHEMBL2024020
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000246 NCI-H292 Homo sapiens (Human)  1
1
IC50 = 56.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 8.9 nM