General Information of the Compound
Compound ID
CP0360936
Compound Name
(R)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid
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Synonyms
K-877
Pemafibrate
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Structure
Formula
C28H30N2O6
Molecular Weight
490.556
Canonical SMILES
CC[C@@H](Oc1cccc(CN(CCCOc2ccc(OC)cc2)c2nc3ccccc3o2)c1)C(O)=O
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InChI
InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1
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InChIKey
ZHKNLJLMDFQVHJ-RUZDIDTESA-N
CAS
848259-27-8
Physicochemical Property
logP
5.5541
Rotatable Bonds
13
Heavy Atom Count
36
Polar Areas
94.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11526038
SID: 16627988
ChEMBL ID
CHEMBL247951
DrugBank ID
DB15212
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Pemafibrate )
Drug Name Pemafibrate
Company Kowa Co Ltd
Indication
Hyperlipidemia
Approved
Lipid metabolism disorder
Phase 3
Cardiovascular disease
Phase 3
Target(s)
Peroxisome proliferator-activated receptor alpha (PPARA)
Agonist