General Information of the Compound
Compound ID
CP0357720
Compound Name
1-[(3,5-difluorophenyl)methyl]-2-oxo-N-[[2-(trifluoromethyl)phenyl]methyl]-3H-benzimidazole-5-carboxamide
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Structure
Formula
C23H16F5N3O2
Molecular Weight
461.39
Canonical SMILES
Fc1cc(F)cc(Cn2c3ccc(cc3[nH]c2=O)C(=O)NCc2ccccc2C(F)(F)F)c1
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InChI
InChI=1S/C23H16F5N3O2/c24-16-7-13(8-17(25)10-16)12-31-20-6-5-14(9-19(20)30-22(31)33)21(32)29-11-15-3-1-2-4-18(15)23(26,27)28/h1-10H,11-12H2,(H,29,32)(H,30,33)
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InChIKey
KDNXIJSEWOBTKX-UHFFFAOYSA-N
Physicochemical Property
logP
4.6049
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
66.89
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166626519
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
EC50 = 1960 nM
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