General Information of the Compound
Compound ID
CP0352950
Compound Name
N-[4-[[3-butyl-1-[(2-fluorophenyl)methyl]-2,6-dioxo-7H-purin-8-yl]methyl]phenyl]-5-chloro-1,3-dimethylpyrazole-4-sulfonamide
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Structure
Formula
C28H29ClFN7O4S
Molecular Weight
614.103
Canonical SMILES
CCCCn1c2nc(Cc3ccc(NS(=O)(=O)c4c(C)nn(C)c4Cl)cc3)[nH]c2c(=O)n(Cc2ccccc2F)c1=O
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InChI
InChI=1S/C28H29ClFN7O4S/c1-4-5-14-36-26-23(27(38)37(28(36)39)16-19-8-6-7-9-21(19)30)31-22(32-26)15-18-10-12-20(13-11-18)34-42(40,41)24-17(2)33-35(3)25(24)29/h6-13,34H,4-5,14-16H2,1-3H3,(H,31,32)
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InChIKey
MTTQDSZMHKSAMH-UHFFFAOYSA-N
Physicochemical Property
logP
3.96072
Rotatable Bonds
10
Heavy Atom Count
42
Polar Areas
136.67
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10438766
SID: 15458609
ChEMBL ID
CHEMBL243116
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06048, Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000298 H4-II-E Rattus norvegicus (Rat)  1
1
EC50 = 3970 nM
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