General Information of the Compound
Compound ID
CP0326988
Compound Name
LEQ-506
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Synonyms
LEQ-506
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Structure
Formula
C25H32N6O
Molecular Weight
432.572
Canonical SMILES
C[C@@H]1CN(CCN1c1cnc(cn1)C(C)(C)O)c1nnc(Cc2ccccc2)c(C)c1C
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InChI
InChI=1S/C25H32N6O/c1-17-16-30(11-12-31(17)23-15-26-22(14-27-23)25(4,5)32)24-19(3)18(2)21(28-29-24)13-20-9-7-6-8-10-20/h6-10,14-15,17,32H,11-13,16H2,1-5H3/t17-/m1/s1
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InChIKey
POERAARDVFVDLO-QGZVFWFLSA-N
CAS
1204975-42-7
Physicochemical Property
logP
3.41674
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
78.27
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45100669
SID: 87544960
ChEMBL ID
CHEMBL3133037
DrugBank ID
DB12857
Clinical Information about the Compound
Drug 1 ( LEQ-506 )
Drug Name LEQ-506
Indication
Solid tumour/cancer
Phase 1
Target(s)
Smoothened homolog (SMO)
Inhibitor