General Information of the Compound
Compound ID
CP0320140
Compound Name
2-((6-(2-(2-(4-cyanophenyl)-5-methyloxazol-4-yl)ethoxy)pyridin-3-yl)methyl)-tetrahydrofuran-2-carboxylic acid
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Structure
Formula
C24H23N3O5
Molecular Weight
433.464
Canonical SMILES
Cc1oc(nc1CCOc1ccc(CC2(CCCO2)C(O)=O)cn1)-c1ccc(cc1)C#N
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InChI
InChI=1S/C24H23N3O5/c1-16-20(27-22(32-16)19-6-3-17(14-25)4-7-19)9-12-30-21-8-5-18(15-26-21)13-24(23(28)29)10-2-11-31-24/h3-8,15H,2,9-13H2,1H3,(H,28,29)
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InChIKey
YWXSUMRZNARHPW-UHFFFAOYSA-N
Physicochemical Property
logP
3.7145
Rotatable Bonds
8
Heavy Atom Count
32
Polar Areas
118.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44419772
ChEMBL ID
CHEMBL217907
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 31 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 314 nM
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 334 nM