General Information of the Compound
Compound ID
CP0318091
Compound Name
(1R,7S)-1,3,10,10-tetramethyl-4-[[3-(2-methylphenyl)phenyl]methyl]-3,4-diazatricyclo[5.2.1.02,6]dec-2(6)-en-5-one
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Structure
Formula
C26H30N2O
Molecular Weight
386.539
Canonical SMILES
Cc1ccccc1-c1cccc(Cn2n(C)c3c([C@H]4CC[C@]3(C)C4(C)C)c2=O)c1
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InChI
InChI=1S/C26H30N2O/c1-17-9-6-7-12-20(17)19-11-8-10-18(15-19)16-28-24(29)22-21-13-14-26(4,25(21,2)3)23(22)27(28)5/h6-12,15,21H,13-14,16H2,1-5H3/t21-,26+/m1/s1
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InChIKey
DZLSEJMVWUJDBE-RLWLMLJZSA-N
Physicochemical Property
logP
5.38542
Rotatable Bonds
3
Heavy Atom Count
29
Polar Areas
26.93
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90644192
ChEMBL ID
CHEMBL3291358
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01107, 11-beta-hydroxysteroid dehydrogenase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 15 nM
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