General Information of the Compound
Compound ID
CP0317360
Compound Name
(2S)-N-[4-(3-cyano-1-ethylindol-5-yl)oxyphenyl]-N-methyl-5-oxopyrrolidine-2-carboxamide
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Structure
Formula
C23H22N4O3
Molecular Weight
402.454
Canonical SMILES
CCn1cc(C#N)c2cc(Oc3ccc(cc3)N(C)C(=O)[C@@H]3CCC(=O)N3)ccc12
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InChI
InChI=1S/C23H22N4O3/c1-3-27-14-15(13-24)19-12-18(8-10-21(19)27)30-17-6-4-16(5-7-17)26(2)23(29)20-9-11-22(28)25-20/h4-8,10,12,14,20H,3,9,11H2,1-2H3,(H,25,28)/t20-/m0/s1
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InChIKey
UUCVHXXJITYQAQ-FQEVSTJZSA-N
Physicochemical Property
logP
3.56658
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
87.36
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118735783
ChEMBL ID
CHEMBL3422669
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02399, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 531 nM