General Information of the Compound
Compound ID
CP0308758
Compound Name
1-[(4aS)-6-(benzenesulfonyl)-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-N,N-dimethylmethanamine
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Structure
Formula
C25H27FN4O2S
Molecular Weight
466.582
Canonical SMILES
CN(C)C[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C25H27FN4O2S/c1-28(2)17-25-15-19-16-27-30(22-10-8-21(26)9-11-22)24(19)14-20(25)12-13-29(18-25)33(31,32)23-6-4-3-5-7-23/h3-11,14,16H,12-13,15,17-18H2,1-2H3/t25-/m0/s1
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InChIKey
HKUNJKBHBDFSIE-VWLOTQADSA-N
Physicochemical Property
logP
3.5935
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
58.44
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11525591
SID: 16627554
ChEMBL ID
CHEMBL257203
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000229 SW1353 Homo sapiens (Human)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.1 nM