General Information of the Compound
Compound ID
CP0303655
Compound Name
3-(dimethylamino)propyl N-[3-[[3-(3,5-difluorophenyl)-6-oxopyridazin-1-yl]methyl]phenyl]carbamate
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Structure
Formula
C23H24F2N4O3
Molecular Weight
442.466
Canonical SMILES
CN(C)CCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-c2cc(F)cc(F)c2)c1
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InChI
InChI=1S/C23H24F2N4O3/c1-28(2)9-4-10-32-23(31)26-20-6-3-5-16(11-20)15-29-22(30)8-7-21(27-29)17-12-18(24)14-19(25)13-17/h3,5-8,11-14H,4,9-10,15H2,1-2H3,(H,26,31)
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InChIKey
DZAVNSDHPJBMQG-UHFFFAOYSA-N
Physicochemical Property
logP
3.737
Rotatable Bonds
8
Heavy Atom Count
32
Polar Areas
76.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16122938
ChEMBL ID
CHEMBL3402743
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01201, Hepatocyte growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 42 nM