General Information of the Compound
Compound ID
CP0300127
Compound Name
2-[[5-(dimethylamino)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methylpentan-2-ol
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Structure
Formula
C23H27F4N3O
Molecular Weight
437.481
Canonical SMILES
CN(C)c1cc2cc(CC(O)(CC(C)(C)c3cc(F)ccc3C)C(F)(F)F)[nH]c2cn1
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InChI
InChI=1S/C23H27F4N3O/c1-14-6-7-16(24)10-18(14)21(2,3)13-22(31,23(25,26)27)11-17-8-15-9-20(30(4)5)28-12-19(15)29-17/h6-10,12,29,31H,11,13H2,1-5H3
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InChIKey
GJXAQWRUPWTIBX-UHFFFAOYSA-N
Physicochemical Property
logP
5.28022
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
52.15
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 69571559
ChEMBL ID
CHEMBL3358927
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000227 HFF Homo sapiens (Human)  1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM