General Information of the Compound
Compound ID
CP0293093
Compound Name
6-(2-(2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethylamino)ethylamino)nicotinonitrile
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Synonyms
1H-Pyrazole-5-carbonitrile, 1-(((2-((5-cyano-2-pyridinyl)amino)ethyl)amino)acetyl)-4,5-dihydro-
3-Pyridinecarbonitrile, 6-((2-((2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl)amino)ethyl)amino)-
6-(2-(2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethylamino)ethylamino)nicotinonitrile
6-{2-[2-(5-Cyano-4,5-dihydro-pyrazol-1-yl)-2-oxo-ethylamino]-ethylamino}-nicotinonitrile
761414-79-3
AOB5513
BDBM50150854
CHEMBL184651
KR-60436 free base
KR-62436
NCGC00165817-01
SCHEMBL1083441
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Structure
Formula
C14H15N7O
Molecular Weight
297.322
Canonical SMILES
O=C(CNCCNc1ccc(cn1)C#N)N1N=CCC1C#N
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InChI
InChI=1S/C14H15N7O/c15-7-11-1-2-13(19-9-11)18-6-5-17-10-14(22)21-12(8-16)3-4-20-21/h1-2,4,9,12,17H,3,5-6,10H2,(H,18,19)
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InChIKey
XNYVGGJJENHRBZ-UHFFFAOYSA-N
Physicochemical Property
logP
0.06506
Rotatable Bonds
6
Heavy Atom Count
22
Polar Areas
117.2
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11403745
SID: 16499232
ChEMBL ID
CHEMBL184651
Clinical Information about the Compound
Drug 1 ( KR-62436 )
Drug Name KR-62436
Indication
Non-insulin dependent diabetes
Investigative
Target(s)
Dipeptidyl peptidase 4 (DPP-4)
Inhibitor