General Information of the Compound
Compound ID
CP0288341
Compound Name
N-[4-[[2-(4-tert-butylphenyl)sulfonyl-6-oxo-3,4,7,8-tetrahydro-1H-isoquinolin-8a-yl]methyl]phenyl]methanesulfonamide
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Structure
Formula
C27H34N2O5S2
Molecular Weight
530.712
Canonical SMILES
CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCC2=CC(=O)CCC2(Cc2ccc(NS(C)(=O)=O)cc2)C1
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InChI
InChI=1S/C27H34N2O5S2/c1-26(2,3)21-7-11-25(12-8-21)36(33,34)29-16-14-22-17-24(30)13-15-27(22,19-29)18-20-5-9-23(10-6-20)28-35(4,31)32/h5-12,17,28H,13-16,18-19H2,1-4H3
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InChIKey
AWPOTUYYRPWLEJ-UHFFFAOYSA-N
Physicochemical Property
logP
4.2684
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
100.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44442980
ChEMBL ID
CHEMBL247815
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000229 SW1353 Homo sapiens (Human)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS