General Information of the Compound
Compound ID
CP0287737
Compound Name
[4-(2-methoxyethyl)piperazin-1-yl]-[3-(4-methylphenyl)-1-adamantyl]methanone
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Structure
Formula
C25H36N2O2
Molecular Weight
396.575
Canonical SMILES
COCCN1CCN(CC1)C(=O)C12CC3CC(C1)CC(C3)(C2)c1ccc(C)cc1
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InChI
InChI=1S/C25H36N2O2/c1-19-3-5-22(6-4-19)24-14-20-13-21(15-24)17-25(16-20,18-24)23(28)27-9-7-26(8-10-27)11-12-29-2/h3-6,20-21H,7-18H2,1-2H3
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InChIKey
BSZOCOACUXDBOE-UHFFFAOYSA-N
Physicochemical Property
logP
3.62362
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
32.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 42921990
ChEMBL ID
CHEMBL245511
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01107, 11-beta-hydroxysteroid dehydrogenase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2100 nM
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