General Information of the Compound
Compound ID
CP0285429
Compound Name
3,6-bis[5-(pyrrolidin-1-yl)pentanamido]-9-[4'-(N,N-dimethylamino)anilino]acridine
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Structure
Formula
C39H51N7O2
Molecular Weight
649.884
Canonical SMILES
CN(C)c1ccc(Nc2c3ccc(NC(=O)CCCCN4CCCC4)cc3nc3cc(NC(=O)CCCCN4CCCC4)ccc23)cc1
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InChI
InChI=1S/C39H51N7O2/c1-44(2)32-17-13-29(14-18-32)42-39-33-19-15-30(40-37(47)11-3-5-21-45-23-7-8-24-45)27-35(33)43-36-28-31(16-20-34(36)39)41-38(48)12-4-6-22-46-25-9-10-26-46/h13-20,27-28H,3-12,21-26H2,1-2H3,(H,40,47)(H,41,48)(H,42,43)
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InChIKey
JANBDPPHVAVVMX-UHFFFAOYSA-N
Physicochemical Property
logP
7.6068
Rotatable Bonds
15
Heavy Atom Count
48
Polar Areas
92.84
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11541962
SID: 16643984
ChEMBL ID
CHEMBL202167
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01466, Telomerase reverse transcriptase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000072 A2780 Homo sapiens (Human)  1
1
EC50 = 1930 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CL000411 IMR-90 Homo sapiens (Human)  1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS