General Information of the Compound
Compound ID
CP0282476
Compound Name
1-[3-(Methylsulfonyl)phenyl]-4-propylpiperazine
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Synonyms
1-[3-(Methylsulfonyl)phenyl]-4-propylpiperazine
BDBM50308027
CHEMBL596801
IIFAQXPNYXJBMU-UHFFFAOYSA-N
SCHEMBL3453749
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Structure
Formula
C14H22N2O2S
Molecular Weight
282.409
Canonical SMILES
CCCN1CCN(CC1)c1cccc(c1)S(C)(=O)=O
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InChI
InChI=1S/C14H22N2O2S/c1-3-7-15-8-10-16(11-9-15)13-5-4-6-14(12-13)19(2,17)18/h4-6,12H,3,7-11H2,1-2H3
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InChIKey
IIFAQXPNYXJBMU-UHFFFAOYSA-N
Physicochemical Property
logP
1.6221
Rotatable Bonds
4
Heavy Atom Count
19
Polar Areas
40.62
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
19

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11529282
SID: 16631295
ChEMBL ID
CHEMBL596801
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 664 nM
   TI
   LI
   LO
   TS
2
Ki = 1211 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 1-[3-(Methylsulfonyl)phenyl]-4-propylpiperazine )
Drug Name 1-[3-(Methylsulfonyl)phenyl]-4-propylpiperazine
Target(s)
Dopamine D2 receptor (D2R)
Inhibitor