General Information of the Compound
Compound ID
CP0273066
Compound Name
6-Oxo-6-pyrrolidin-1-yl-hexanoic acid {4-[3,6-bis-(3-pyrrolidin-1-yl-propionylamino)-acridin-9-ylamino]-phenyl}-amide
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Structure
Formula
C43H54N8O4
Molecular Weight
746.957
Canonical SMILES
O=C(CCCCC(=O)N1CCCC1)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
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InChI
InChI=1S/C43H54N8O4/c52-39(9-1-2-10-42(55)51-25-7-8-26-51)44-31-11-13-32(14-12-31)47-43-35-17-15-33(45-40(53)19-27-49-21-3-4-22-49)29-37(35)48-38-30-34(16-18-36(38)43)46-41(54)20-28-50-23-5-6-24-50/h11-18,29-30H,1-10,19-28H2,(H,44,52)(H,45,53)(H,46,54)(H,47,48)
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InChIKey
LEMJBKXSKVGUTP-UHFFFAOYSA-N
Physicochemical Property
logP
7.1017
Rotatable Bonds
16
Heavy Atom Count
55
Polar Areas
139.01
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
55

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44392875
ChEMBL ID
CHEMBL181970
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01466, Telomerase reverse transcriptase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000072 A2780 Homo sapiens (Human)  1
1
IC50 = 318 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 318 nM