General Information of the Compound
Compound ID
CP0271016
Compound Name
14-(dimethylsulfamoylamino)-2-oxo-5-(1-pyridin-2-ylpyrazol-4-yl)-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
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Structure
Formula
C24H20N6O3S
Molecular Weight
472.53
Canonical SMILES
CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(c1)-c1ccccn1
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InChI
InChI=1S/C24H20N6O3S/c1-29(2)34(32,33)28-19-8-6-16-7-9-22-21(24(31)20(16)12-19)11-17(13-26-22)18-14-27-30(15-18)23-5-3-4-10-25-23/h3-15,28H,1-2H3
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InChIKey
LJJNUHXTGGXNRD-UHFFFAOYSA-N
Physicochemical Property
logP
3.2142
Rotatable Bonds
5
Heavy Atom Count
34
Polar Areas
110.08
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53310825
SID: 124770275
ChEMBL ID
CHEMBL1802905
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01201, Hepatocyte growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000282 GTL-16 Homo sapiens (Human)  1
1
IC50 = 750 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 130 nM