General Information of the Compound
Compound ID
CP0252776
Compound Name
(4aR,11R,11aS)-11-methyl-2-[2-(oxan-4-yl)ethyl]-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazole
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Structure
Formula
C24H31F3N2O
Molecular Weight
420.519
Canonical SMILES
C[C@@H]1[C@H]2CN(CCC3CCOCC3)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F
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InChI
InChI=1S/C24H31F3N2O/c1-15-20-14-29(8-4-16-6-10-30-11-7-16)9-5-17(20)12-22-23(15)19-13-18(24(25,26)27)2-3-21(19)28-22/h2-3,13,15-17,20,28H,4-12,14H2,1H3/t15-,17-,20-/m1/s1
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InChIKey
ZJWXPPLSZFSNGB-WRWLIDTKSA-N
Physicochemical Property
logP
5.6011
Rotatable Bonds
3
Heavy Atom Count
30
Polar Areas
28.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57393332
ChEMBL ID
CHEMBL1922269
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.9 nM