General Information of the Compound
Compound ID
CP0242066
Compound Name
2-(5-chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)pyrimidin-4-ylamino)-N-methylbenzamide
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Structure
Formula
C24H25ClN6O2
Molecular Weight
464.957
Canonical SMILES
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3NC(=O)CCC(C)(C)c3c2)ncc1Cl
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InChI
InChI=1S/C24H25ClN6O2/c1-24(2)11-10-20(32)29-19-9-8-14(12-16(19)24)28-23-27-13-17(25)21(31-23)30-18-7-5-4-6-15(18)22(33)26-3/h4-9,12-13H,10-11H2,1-3H3,(H,26,33)(H,29,32)(H2,27,28,30,31)
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InChIKey
FVAJHBVTGUIFMD-UHFFFAOYSA-N
Physicochemical Property
logP
4.9867
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
108.04
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53321285
ChEMBL ID
CHEMBL1644804
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01201, Hepatocyte growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000282 GTL-16 Homo sapiens (Human)  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 54 nM