General Information of the Compound
Compound ID
CP0241994
Compound Name
3-(2,2-dimethylpropanoyl)-4-hydroxy-2-[2-(2-hydroxyethoxy)phenyl]-1-[4-(1,2-oxazol-3-yl)phenyl]-2H-pyrrol-5-one
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Structure
Formula
C26H26N2O6
Molecular Weight
462.502
Canonical SMILES
CC(C)(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCCO)c1ccc(cc1)-c1ccon1
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InChI
InChI=1S/C26H26N2O6/c1-26(2,3)24(31)21-22(18-6-4-5-7-20(18)33-15-13-29)28(25(32)23(21)30)17-10-8-16(9-11-17)19-12-14-34-27-19/h4-12,14,22,29-30H,13,15H2,1-3H3
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InChIKey
IUCLLEZQKXRIJZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.2279
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
113.1
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58365945
ChEMBL ID
CHEMBL4565775
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03393, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000093 C6-BU-1 Rattus norvegicus (Rat)  1
1
IC50 = 82 nM
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