General Information of the Compound
Compound ID
CP0215833
Compound Name
(2,6-Dimethyl-phenyl)-[4'-methyl-4-(4-methyl-benzyl)-[1,4']bipiperidinyl-1'-yl]-methanone
    Show/Hide
Structure
Formula
C28H38N2O
Molecular Weight
418.625
Canonical SMILES
Cc1ccc(CC2CCN(CC2)C2(C)CCN(CC2)C(=O)c2c(C)cccc2C)cc1
    Show/Hide
InChI
InChI=1S/C28H38N2O/c1-21-8-10-24(11-9-21)20-25-12-16-30(17-13-25)28(4)14-18-29(19-15-28)27(31)26-22(2)6-5-7-23(26)3/h5-11,25H,12-20H2,1-4H3
    Show/Hide
InChIKey
KXMNHKYDYLLZNM-UHFFFAOYSA-N
Physicochemical Property
logP
5.56126
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 511295
SID: 15979045
ChEMBL ID
CHEMBL110786
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05087, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
Ki = 113 nM
   TI
   LI
   LO
   TS