General Information of the Compound
Compound ID
CP0181668
Compound Name
4-(2-(4-chlorobenzyloxy)-5-bromobenzyl)morpholine
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Synonyms
4-(2-(4-chlorobenzyloxy)-5-bromobenzyl)morpholine
4-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]morpholine
851546-84-4
CHEMBL391379
CTK3C9230
DTXSID80458181
Morpholine, 4-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-
SCHEMBL5699765
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Structure
Formula
C18H19BrClNO2
Molecular Weight
396.712
Canonical SMILES
Clc1ccc(COc2ccc(Br)cc2CN2CCOCC2)cc1
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InChI
InChI=1S/C18H19BrClNO2/c19-16-3-6-18(23-13-14-1-4-17(20)5-2-14)15(11-16)12-21-7-9-22-10-8-21/h1-6,11H,7-10,12-13H2
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InChIKey
JUKUHNUKMFGLIK-UHFFFAOYSA-N
Physicochemical Property
logP
4.5137
Rotatable Bonds
5
Heavy Atom Count
23
Polar Areas
21.7
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11188669
SID: 16269691
ChEMBL ID
CHEMBL391379
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1000 nM
Clinical Information about the Compound
Drug 1 ( 4-(2-(4-chlorobenzyloxy)-5-bromobenzyl)morpholine )
Drug Name 4-(2-(4-chlorobenzyloxy)-5-bromobenzyl)morpholine
Target(s)
C-C chemokine receptor type 5 (CCR5)
Inhibitor