General Information of the Compound
Compound ID
CP0176149
Compound Name
2-methoxy-N-[2-[2-[[(1S)-1-(4-methoxyphenyl)ethyl]amino]-2-oxoethyl]sulfanyl-1,3-benzothiazol-6-yl]-3-methyl-4-pentan-2-yloxybenzamide
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Structure
Formula
C32H37N3O5S2
Molecular Weight
607.798
Canonical SMILES
CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccc(OC)cc4)sc3c2)c(OC)c1C
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InChI
InChI=1S/C32H37N3O5S2/c1-7-8-19(2)40-27-16-14-25(30(39-6)20(27)3)31(37)34-23-11-15-26-28(17-23)42-32(35-26)41-18-29(36)33-21(4)22-9-12-24(38-5)13-10-22/h9-17,19,21H,7-8,18H2,1-6H3,(H,33,36)(H,34,37)/t19?,21-/m0/s1
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InChIKey
NNSKHOBWYYGACP-QWAKEFERSA-N
Physicochemical Property
logP
7.41112
Rotatable Bonds
13
Heavy Atom Count
42
Polar Areas
98.78
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 141483850
ChEMBL ID
CHEMBL4846365
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02212, Signal transducer and activator of transcription 1-alpha/beta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
Protein ID: PT01503, Signal transducer and activator of transcription 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 53.04 nM