General Information of the Compound
Compound ID
CP0170803
Compound Name
2-imidazol-1-yl-N-[5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]ethanesulfonamide
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Structure
Formula
C23H20N6O3S
Molecular Weight
460.519
Canonical SMILES
Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)CCn4ccnc4)cc3c(=O)c2c1
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InChI
InChI=1S/C23H20N6O3S/c1-28-14-18(13-26-28)17-10-21-22(25-12-17)5-3-16-2-4-19(11-20(16)23(21)30)27-33(31,32)9-8-29-7-6-24-15-29/h2-7,10-15,27H,8-9H2,1H3
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InChIKey
MFOGSAOKLGJVCE-UHFFFAOYSA-N
Physicochemical Property
logP
2.7871
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
111.77
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53310544
SID: 124769960
ChEMBL ID
CHEMBL1802828
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01201, Hepatocyte growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000282 GTL-16 Homo sapiens (Human)  1
1
IC50 = 7300 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 13 nM