General Information of the Compound
Compound ID
CP0169300
Compound Name
(20R)-23-amino-17-fluoro-5,12,20-trimethyl-21-oxa-3,7,9,12,24-pentazapentacyclo[20.3.1.02,10.03,8.014,19]hexacosa-1(26),2(10),4,6,8,14(19),15,17,22,24-decaen-13-one
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Structure
Formula
C23H21FN6O2
Molecular Weight
432.459
Canonical SMILES
C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nc1ncc(C)cn21
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InChI
InChI=1S/C23H21FN6O2/c1-12-8-27-23-28-18-11-29(3)22(31)16-5-4-15(24)7-17(16)13(2)32-19-6-14(9-26-21(19)25)20(18)30(23)10-12/h4-10,13H,11H2,1-3H3,(H2,25,26)/t13-/m1/s1
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InChIKey
LOLWMDGFTABZFN-CYBMUJFWSA-N
Physicochemical Property
logP
3.54662
Rotatable Bonds
0
Heavy Atom Count
32
Polar Areas
98.64
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89808125
ChEMBL ID
CHEMBL3286831
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01203, ALK tyrosine kinase receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
IC50 = 365 nM
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