General Information of the Compound
Compound ID
CP0169204
Compound Name
10-(2-diethylaminopropyl)phenothiazine
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Synonyms
10-(2-Diethylaminopropyl)phenothiazine
10-[2-(Diethylamino)-1-Propyl]phenothiazine;10-[2-(Diethylamino)-2-methylethyl]phenothiazine
10-[2-(Diethylamino)propyl]phenothiazine
2-Diethylamino-1-propyl-N-dibenzoparathiazine
Aethopropropazin
Athapropazine
Athopropazin
Ethapropazine
Ethopromazine
Ethopropazine
Etopropezina
Fempropazine
Fenpropazina
Isopthazine
Isotazin
Isothazine
Isothiazine
Lysivane
N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine
N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine
N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine
Parcidol
Pardidol
Parfezine
Parkin
Parkin (TN)
Parkisol
Parsidan
Parsidan (TN)
Parsidol
Parsidol(TN)
Parsitan
Parsotil
Phenopropazine
Phenoprozine
Prodictazin
Prodierazine
Profenamina
Profenamina [INN-Spanish]
Profenamina [Italian]
Profenamine
Profenamine (INN)
Profenamine [INN:BAN]
Profenaminum
Profenaminum [INN-Latin]
Prophenamine
Prophenaminum
RP 3356
Rochipel
Rocipel
Rodipal
SC 2538
SKF 2538
W 483
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Structure
Formula
C19H24N2S
Molecular Weight
312.482
Canonical SMILES
CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12
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InChI
InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
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InChIKey
CDOZDBSBBXSXLB-UHFFFAOYSA-N
CAS
522-00-9
Physicochemical Property
logP
5.0196
Rotatable Bonds
5
Heavy Atom Count
22
Polar Areas
6.48
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3290
SID: 14923459
ChEMBL ID
CHEMBL1206
DrugBank ID
DB00392
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03795, Solute carrier family 22 member 1
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 20460 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Ethopropazine )
Drug Name Ethopropazine
Indication
Parkinson disease
Approved
Target(s)
Histamine H1 receptor (H1R)
 Target Info 
Modulator