General Information of the Compound
Compound ID
CP0166219
Compound Name
3-(2-Methyl-piperidin-1-yl)-N-{7-[3-(2-methyl-piperidin-1-yl)-propionylamino]-9-oxo-9,10-dihydro-acridin-2-yl}-propionamide
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Structure
Formula
C31H41N5O3
Molecular Weight
531.701
Canonical SMILES
CC1CCCCN1CCC(=O)Nc1ccc2nc3ccc(NC(=O)CCN4CCCCC4C)cc3c(O)c2c1
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InChI
InChI=1S/C31H41N5O3/c1-21-7-3-5-15-35(21)17-13-29(37)32-23-9-11-27-25(19-23)31(39)26-20-24(10-12-28(26)34-27)33-30(38)14-18-36-16-6-4-8-22(36)2/h9-12,19-22H,3-8,13-18H2,1-2H3,(H,32,37)(H,33,38)(H,34,39)
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InChIKey
AUEWEHMRNGTAAA-UHFFFAOYSA-N
Physicochemical Property
logP
5.4996
Rotatable Bonds
8
Heavy Atom Count
39
Polar Areas
97.8
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 21074073
ChEMBL ID
CHEMBL186848
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01466, Telomerase reverse transcriptase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000072 A2780 Homo sapiens (Human)  1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 2300 nM