General Information of the Compound
Compound ID
CP0154360
Compound Name
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-17-[2-(6-methylpyridin-2-yl)sulfanylacetyl]-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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Structure
Formula
C27H35NO4S
Molecular Weight
469.647
Canonical SMILES
Cc1cccc(SCC(=O)[C@@]2(O)CC[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]23C)n1
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InChI
InChI=1S/C27H35NO4S/c1-16-5-4-6-23(28-16)33-15-22(31)27(32)12-10-20-19-8-7-17-13-18(29)9-11-25(17,2)24(19)21(30)14-26(20,27)3/h4-6,13,19-21,24,30,32H,7-12,14-15H2,1-3H3/t19-,20-,21-,24+,25-,26-,27-/m0/s1
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InChIKey
VWZSOSFXYJBTSQ-FOMYWIRZSA-N
Physicochemical Property
logP
4.28502
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
87.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 70689841
ChEMBL ID
CHEMBL2024029
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000246 NCI-H292 Homo sapiens (Human)  1
1
IC50 = 127 nM
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