General Information of the Compound
Compound ID
CP0139973
Compound Name
4-hydroxy-3-(2-methylpropanoyl)-2-[2-(2-methylsulfinylethoxy)phenyl]-1-(4-thiophen-3-ylphenyl)-2H-pyrrol-5-one
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Structure
Formula
C27H27NO5S2
Molecular Weight
509.649
Canonical SMILES
CC(C)C(=O)C1=C(O)C(=O)N(C1c1ccccc1OCC[S+](C)[O-])c1ccc(cc1)-c1ccsc1
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InChI
InChI=1S/C27H27NO5S2/c1-17(2)25(29)23-24(21-6-4-5-7-22(21)33-13-15-35(3)32)28(27(31)26(23)30)20-10-8-18(9-11-20)19-12-14-34-16-19/h4-12,14,16-17,24,30H,13,15H2,1-3H3
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InChIKey
WLLMHLXFTTYNGV-UHFFFAOYSA-N
Physicochemical Property
logP
5.2975
Rotatable Bonds
9
Heavy Atom Count
35
Polar Areas
89.9
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58365527
ChEMBL ID
CHEMBL4437131
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03393, P2X purinoceptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000093 C6-BU-1 Rattus norvegicus (Rat)  1
1
IC50 = 13 nM
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