General Information of the Compound
Compound ID
CP0130353
Compound Name
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
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Structure
Formula
C22H25N3O3S3
Molecular Weight
475.661
Canonical SMILES
Cc1ccc(\C=N\NC(=O)[C@@H]2CC3(CN2S(=O)(=O)c2ccc(C)cc2)SCCS3)cc1
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InChI
InChI=1S/C21H23ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-10,17H,1-2,11-15H2
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InChIKey
ISTLEDHRAMPSGK-UHFFFAOYSA-N
Physicochemical Property
logP
3.39304
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
78.84
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11382826
SID: 16476763
ChEMBL ID
CHEMBL147830
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
Kd = 1.905 nM
   TI
   LI
   LO
   TS
2
Ki = 1.738 nM
   TI
   LI
   LO
   TS