General Information of the Compound
Compound ID
CP0109245
Compound Name
2-[4-[[2,3-dimethyl-5-[[(1S)-1-(4-propan-2-ylphenyl)ethyl]carbamoyl]indol-1-yl]methyl]phenyl]benzoic acid
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Structure
Formula
C36H36N2O3
Molecular Weight
544.695
Canonical SMILES
CC(C)c1ccc(cc1)[C@H](C)NC(=O)c1ccc2n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c(C)c(C)c2c1
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InChI
InChI=1S/C36H36N2O3/c1-22(2)27-14-16-28(17-15-27)24(4)37-35(39)30-18-19-34-33(20-30)23(3)25(5)38(34)21-26-10-12-29(13-11-26)31-8-6-7-9-32(31)36(40)41/h6-20,22,24H,21H2,1-5H3,(H,37,39)(H,40,41)/t24-/m0/s1
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InChIKey
ZVFXZTVFMARNCX-DEOSSOPVSA-N
Physicochemical Property
logP
8.28604
Rotatable Bonds
8
Heavy Atom Count
41
Polar Areas
71.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53362018
ChEMBL ID
CHEMBL3735674
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
EC50 = 1141 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 13 nM