General Information of the Compound
Compound ID
CP0100961
Compound Name
7-[4-[[(5S,5aS,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-5-yl]amino]phenoxy]-N-(2-aminophenyl)heptanamide
    Show/Hide
Structure
Formula
C40H43N3O9
Molecular Weight
709.796
Canonical SMILES
COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](Nc2ccc(OCCCCCCC(=O)Nc3ccccc3N)cc2)c2cc3OCOc3cc12
    Show/Hide
InChI
InChI=1S/C40H43N3O9/c1-47-33-17-23(18-34(48-2)39(33)45)36-26-19-31-32(52-22-51-31)20-27(26)38(28-21-50-40(46)37(28)36)42-24-12-14-25(15-13-24)49-16-8-4-3-5-11-35(44)43-30-10-7-6-9-29(30)41/h6-7,9-10,12-15,17-20,28,36-38,42,45H,3-5,8,11,16,21-22,41H2,1-2H3,(H,43,44)/t28-,36+,37-,38+/m0/s1
    Show/Hide
InChIKey
FVZDLGVIWKVAIO-GHCWVHGPSA-N
Physicochemical Property
logP
6.7762
Rotatable Bonds
14
Heavy Atom Count
52
Polar Areas
159.83
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
11
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 72696205
ChEMBL ID
CHEMBL2442694
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00991, Histone deacetylase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 14080 nM
   TI
   LI
   LO
   TS
Protein ID: PT00995, Histone deacetylase 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 11620 nM
   TI
   LI
   LO
   TS