General Information of the Compound
Compound ID
CP0099667
Compound Name
(4aR)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
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Synonyms
1018679-79-2
1H-Pyrazolo[3,4-g]isoquinoline, 4a-(ethoxymethyl)-1-(4-fluorophenyl)-4,4a,5,6,7,8-hexahydro-6-[[4-(trifluoromethyl)phenyl]sulfonyl]-, (4aR)-;1H-Pyrazolo[3,4-g]isoquinoline, 4a-(ethoxymethyl)-1-(4-fluorophenyl)-4,4a,5,6,7,8-hexahydro-6-[[4-(trifluoromethyl)phenyl]sulfonyl]-, (4aR)-
A17W0640NB
ADS-108297
AKOS027338706
AS-35226
BCP16798
BDBM50372968
CHEMBL271220
CORT 108297
CORT-108297
Cort108297
DTXSID70144304
KS-0000064X
MolPort-044-723-886
SB17316
SCHEMBL755070
UNII-A17W0640NB
ZINC29128012
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Structure
Formula
C26H25F4N3O3S
Molecular Weight
535.563
Canonical SMILES
CCOC[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(cc1)C(F)(F)F
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InChI
InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1
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InChIKey
SLKURXRZHJOZOD-RUZDIDTESA-N
CAS
1018679-79-2
Physicochemical Property
logP
5.0872
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
64.43
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44454750
SID: 103021655
ChEMBL ID
CHEMBL271220
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000229 SW1353 Homo sapiens (Human)  1
1
Ki = 6.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.9 nM
2 Ki = 6.8 nM
Clinical Information about the Compound
Drug 1 ( CORT-108297 )
Drug Name CORT-108297
Company Corcept Therapeutics
Indication
Weight gain
Discontinued in Phase 1/2