General Information of the Compound
Compound ID
CP0094121
Compound Name
2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-amine
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Synonyms
1H-Benzimidazol-5-amine, 2-(4-thiazolyl)-
2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-amine
2-(4-Thiazolyl)-1H-benzimidazol-5-amine
2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-amine
2-Thiazol-4-yl-3H-benzoimidazol-5-ylamine
25893-06-5
5-Aminothiabendazole
5-amino-2-(thiazol-4-yl)-1H-benzimidazole
5-amino-2-thiazol-4-yl-1H-benzoimidazole
AC1L35H8
AC1Q4XVD
AKOS000129404
BDBM50180749
CHEMBL370420
CTK7D8516
CUDHOGCHOXYXRZ-UHFFFAOYSA-N
MCULE-2929987645
MolPort-004-293-518
SCHEMBL4367564
ZINC13679482
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Structure
Formula
C10H8N4S
Molecular Weight
216.269
Canonical SMILES
Nc1ccc2nc([nH]c2c1)-c1cscn1
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InChI
InChI=1S/C10H8N4S/c11-6-1-2-7-8(3-6)14-10(13-7)9-4-15-5-12-9/h1-5H,11H2,(H,13,14)
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InChIKey
CUDHOGCHOXYXRZ-UHFFFAOYSA-N
CAS
25893-06-5
Physicochemical Property
logP
2.2686
Rotatable Bonds
1
Heavy Atom Count
15
Polar Areas
67.59
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
15

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 134912
SID: 16740282
ChEMBL ID
CHEMBL370420
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00973, Methionine aminopeptidase 2
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 10100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-amine )
Drug Name 2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-amine
Target(s)
Methionine aminopeptidase 2 (METAP2)
 Target Info 
Inhibitor