General Information of the Compound
Compound ID
CP0076718
Compound Name
(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
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Synonyms
(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
(S)-2-(4-Ethyl-phenoxy)-3-phenyl-propionic acid
BDBM50171895
CHEMBL191060
DB07842
ZINC13671697
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Structure
Formula
C17H18O3
Molecular Weight
270.328
Canonical SMILES
CCc1ccc(O[C@@H](Cc2ccccc2)C(O)=O)cc1
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InChI
InChI=1S/C17H18O3/c1-2-13-8-10-15(11-9-13)20-16(17(18)19)12-14-6-4-3-5-7-14/h3-11,16H,2,12H2,1H3,(H,18,19)/t16-/m0/s1
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InChIKey
CJMVTSLLWMPEKQ-INIZCTEOSA-N
Physicochemical Property
logP
3.3237
Rotatable Bonds
6
Heavy Atom Count
20
Polar Areas
46.53
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11149906
SID: 16228523
ChEMBL ID
CHEMBL191060
DrugBank ID
DB07842
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00910, Peroxisome proliferator-activated receptor alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  2
1
EC50 = 700 nM
   TI
   LI
   LO
   TS
2
EC50 = 707.95 nM
   TI
   LI
   LO
   TS
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  2
1
EC50 = 3600 nM
   TI
   LI
   LO
   TS
2
EC50 = 3630.78 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid )
Drug Name (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
Target(s)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Inhibitor