General Information of the Compound
Compound ID
CP0073798
Compound Name
2-methyl-3-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-5-morpholin-4-ylimidazo[4,5-b]pyridine-7-carboxylic acid
    Show/Hide
Structure
Formula
C21H21F3N4O3
Molecular Weight
434.418
Canonical SMILES
Cc1nc2c(cc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O
    Show/Hide
InChI
InChI=1S/C21H21F3N4O3/c1-12-14(4-3-5-16(12)21(22,23)24)11-28-13(2)25-18-15(20(29)30)10-17(26-19(18)28)27-6-8-31-9-7-27/h3-5,10H,6-9,11H2,1-2H3,(H,29,30)
    Show/Hide
InChIKey
DQFJQMDNPRZOAO-UHFFFAOYSA-N
Physicochemical Property
logP
3.65004
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
80.48
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 71612553
ChEMBL ID
CHEMBL2431398
Table of Molecular Bioactivities Related to the Compound
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000196 MDA-MB-468 Homo sapiens (Human)  1
1
EC50 = 41 nM
   TI
   LI
   LO
   TS