General Information of the Compound
Compound ID
CP0070242
Compound Name
N-(Pyridin-2-yl) arylsulfonamide, 26
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Synonyms
388927163B
857290-04-1
AKOS024457530
B7346
BCP28049
BDBM29864
CHEMBL495841
CS-5559
CTK5F5674
DTXSID00235037
HY-18056
KB-274983
KS-00001D9U
MolPort-023-276-737
N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide
N-(6-Aminopyridin-2-yl)4'-cyanobiphenyl-4-sulfonamide
N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide
N-(Pyridin-2-yl) arylsulfonamide, 26
NCGC00370811-01
PF 915275
PF-915275
RT-015014
SCHEMBL4384483
UNII-388927163B
ZESFDAKNYJQYKO-UHFFFAOYSA-N
ZINC40955326
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Structure
Formula
C18H14N4O2S
Molecular Weight
350.403
Canonical SMILES
Nc1cccc(NS(=O)(=O)c2ccc(cc2)-c2ccc(cc2)C#N)n1
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InChI
InChI=1S/C18H14N4O2S/c19-12-13-4-6-14(7-5-13)15-8-10-16(11-9-15)25(23,24)22-18-3-1-2-17(20)21-18/h1-11H,(H3,20,21,22)
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InChIKey
ZESFDAKNYJQYKO-UHFFFAOYSA-N
Physicochemical Property
logP
3.00328
Rotatable Bonds
4
Heavy Atom Count
25
Polar Areas
108.87
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23725123
SID: 47208558
ChEMBL ID
CHEMBL495841
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01107, 11-beta-hydroxysteroid dehydrogenase 1
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki < 1 nM
Clinical Information about the Compound
Drug 1 ( PF-915275 )
Drug Name PF-915275
Indication
Non-insulin dependent diabetes
Discontinued in Phase 1
Target(s)
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
 Target Info 
Inhibitor