General Information of the Compound
Compound ID
CP0066106
Compound Name
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
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Synonyms
(-)-alpha-Amino-p-hydroxyhydrocinnamic acid
(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid
(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
(S)-3-(p-Hydroxyphenyl)alanine
(S)-Tyrosine
(S)-alpha-Amino-4-hydroxybenzenepropanoic acid
2-Amino-3-(p-hydroxyphenyl)propionic acid
3-(4-Hydroxyphenyl)-L-alanine
3-(p-Hydroxyphenyl)alanine
4-Hydroxy-L-phenylalanine
4ts1
Alpha-Amino-beta-(4-hydroxyphenyl)propionic acid
Beta-(p-Hydroxyphenyl)alanine
DD69927C-C6A8-4BC6-8E9A-0AB423B176E7
DTY
Free-Form L-Tyrosine
H-Tyr-OH
L-(-)-Tyrosine
L-2-Amino-3-p-hydroxyphenylpropanoic acid
L-Tyrosin
L-Tyrosine
L-Tyrosine (9CI)
L-Tyrosine (JAN)
L-Tyrosine hydrochloride
L-Tyrosine, homopolymer
L-Tyrosine, monomer
L-p-Tyrosine
Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs
Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide
Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide, <3 kd fraction
Melanin synthesized from Tyr substrate catalyzed by tyrosinase, brominated with N-bromosuccinimide
Melanin synthesized from Tyr substrate catalyzed by tyrosinase, sulfonated using sulfur trioxide/DMF complex for 1.5-7 hours
P-Tyrosine
Rxosine
TYR NH3+ COOH
Tirosina
Tirosina [Spanish]
Tyr
Tyrosine
Tyrosine (USP/INN)
Tyrosine (VAN)
Tyrosine Power
Tyrosine [USAN:INN]
Tyrosine, L-(8CI)
Tyrosinum
Tyrosinum [Latin]
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Structure
Formula
C9H11NO3
Molecular Weight
181.191
Canonical SMILES
N[C@@H](Cc1ccc(O)cc1)C(O)=O
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InChI
InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
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InChIKey
OUYCCCASQSFEME-QMMMGPOBSA-N
CAS
140-43-2
1991-85-1
46209-14-7
55520-40-6
25619-78-7
Physicochemical Property
logP
0.3466
Rotatable Bonds
3
Heavy Atom Count
13
Polar Areas
83.55
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
13

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 6942100
SID: 15147336
ChEMBL ID
CHEMBL925
DrugBank ID
DB00135
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05556, Large neutral amino acids transporter small subunit 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000058 T-REx-293 Homo sapiens (Human)  1
1
IC50 = 68000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( L-Tyrosine )
Drug Name L-Tyrosine
Indication
Malnutrition
Approved
Target(s)
Tyrosine 3-monooxygenase (TH)
Binder