General Information of the Compound
Compound ID
CP0065381
Compound Name
(3S)-3-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-3-cyclopentyloxy-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
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Structure
Formula
C30H47N5O11
Molecular Weight
653.73
Canonical SMILES
CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CC[C@H](OC2CCCC2)[C@H]1C(=O)N[C@H]1CC(=O)OC1O
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InChI
InChI=1S/C30H47N5O11/c1-14(2)23(31-16(5)36)27(41)32-18(12-21(37)38)26(40)34-24(15(3)4)29(43)35-11-10-20(45-17-8-6-7-9-17)25(35)28(42)33-19-13-22(39)46-30(19)44/h14-15,17-20,23-25,30,44H,6-13H2,1-5H3,(H,31,36)(H,32,41)(H,33,42)(H,34,40)(H,37,38)/t18-,19-,20-,23-,24-,25-,30?/m0/s1
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InChIKey
HXMVHUWHZRCCBE-AFIJWPDYSA-N
Physicochemical Property
logP
-1.0738
Rotatable Bonds
14
Heavy Atom Count
46
Polar Areas
229.77
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
10
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56670255
ChEMBL ID
CHEMBL1835315
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03483, Caspase-2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 35667 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 772 nM