General Information of the Compound
| Compound ID |
CP0064394
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| Compound Name |
GSK2141795
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| Synonyms |
1047634-65-0
2-Furancarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-;2-Furancarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
AXTAPYRUEKNRBA-JTQLQIEISA-N
CHEMBL3137336
GSK-2141795
GSK2141795
GSK2141795C
GSK795
GTPL7902
MolPort-044-560-307
SCHEMBL168584
UNII-ZXM835LQ5E
Uprosertib
Uprosertib (GSK2141795)
Uprosertib (USAN/INN)
Uprosertib [USAN:INN]
Uprosertib, GSK2141795
ZXM835LQ5E
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| Structure |
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| Formula |
C18H16Cl2F2N4O2
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| Molecular Weight |
429.254
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| Canonical SMILES |
Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@H](CN)Cc1ccc(F)c(F)c1
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| InChI |
InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
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| InChIKey |
AXTAPYRUEKNRBA-JTQLQIEISA-N
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| CAS |
1047634-65-0
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00845, RAC-alpha serine/threonine-protein kinase
Protein ID: PT01131, RAC-beta serine/threonine-protein kinase
Clinical Information about the Compound