General Information of the Compound
Compound ID
CP0064093
Compound Name
CHEMBL4524977
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Formula
C31H43N7OS
Molecular Weight
561.8
Canonical SMILES
CCSc1ncccc1CNc1ncc(C#N)c(NCC23CC4CC(C2)C(NC[C@H]2CC[C@H](O)CC2)C(C4)C3)n1
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InChI
InChI=1S/C31H43N7OS/c1-2-40-29-22(4-3-9-33-29)17-35-30-36-18-25(15-32)28(38-30)37-19-31-12-21-10-23(13-31)27(24(11-21)14-31)34-16-20-5-7-26(39)8-6-20/h3-4,9,18,20-21,23-24,26-27,34,39H,2,5-8,10-14,16-17,19H2,1H3,(H2,35,36,37,38)/t20-,21?,23?,24?,26-,27?,31?
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InChIKey
IBASXJCALNBKEI-QYPVNRHLSA-N
Physicochemical Property
logP
5.21488
Rotatable Bonds
11
Heavy Atom Count
40
Polar Areas
118.78
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4524977
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01127, Protein kinase C theta type
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 < 3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.46 nM