General Information of the Compound
Compound ID
CP0059051
Compound Name
1-hydroxy-1-(4-(2-(4-phenoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)urea
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Synonyms
A-80040
BDBM50189633
CHEMBL378186
SCHEMBL16705052
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Structure
Formula
C20H17N3O4S
Molecular Weight
395.44
Canonical SMILES
CC(C#Cc1cnc(Oc2ccc(Oc3ccccc3)cc2)s1)N(O)C(N)=O
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InChI
InChI=1S/C20H17N3O4S/c1-14(23(25)19(21)24)7-12-18-13-22-20(28-18)27-17-10-8-16(9-11-17)26-15-5-3-2-4-6-15/h2-6,8-11,13-14,25H,1H3,(H2,21,24)
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InChIKey
MCMUCDFOFIZPSA-UHFFFAOYSA-N
Physicochemical Property
logP
4.2376
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
97.91
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11675600
SID: 16779621
ChEMBL ID
CHEMBL378186
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01270, Acetyl-CoA carboxylase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1000 nM
Protein ID: PT01119, Acetyl-CoA carboxylase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 75 nM
Clinical Information about the Compound
Drug 1 ( A-80040 )
Drug Name A-80040
Target(s)
Acetyl-CoA carboxylase 2 (ACACB)
Inhibitor