General Information of the Compound
Compound ID
CP0051737
Compound Name
6-benzoyl-2-[(4-fluorophenyl)methylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile
    Show/Hide
Structure
Formula
C22H18FN3OS
Molecular Weight
391.471
Canonical SMILES
Fc1ccc(CNc2sc3CN(CCc3c2C#N)C(=O)c2ccccc2)cc1
    Show/Hide
InChI
InChI=1S/C22H18FN3OS/c23-17-8-6-15(7-9-17)13-25-21-19(12-24)18-10-11-26(14-20(18)28-21)22(27)16-4-2-1-3-5-16/h1-9,25H,10-11,13-14H2
    Show/Hide
InChIKey
BJGAJTMYBFSCLX-UHFFFAOYSA-N
Physicochemical Property
logP
4.56948
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
56.13
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 118735971
ChEMBL ID
CHEMBL3422887
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01994, Metabotropic glutamate receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000447 Chem-3 Mus musculus (Mouse)  1
1
IC50 = 1810 nM
   TI
   LI
   LO
   TS