General Information of the Compound
Compound ID
CP0051687
Compound Name
4-{[(4-bromo-phenyl)-(2-{[4-((9S,11R,13S,14S,17S)-17-hydroxy-13-methyl-3-oxo-17-prop-1-ynyl-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)-phenyl]-methyl-amino}-acetyl)-amino]-methyl}-benzoic acid
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Structure
Formula
C44H45BrN2O5
Molecular Weight
761.757
Canonical SMILES
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CC(=O)N(Cc1ccc(cc1)C(O)=O)c1ccc(Br)cc1
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InChI
InChI=1S/C44H45BrN2O5/c1-4-22-44(52)23-21-39-37-19-11-31-24-35(48)18-20-36(31)41(37)38(25-43(39,44)2)29-9-14-33(15-10-29)46(3)27-40(49)47(34-16-12-32(45)13-17-34)26-28-5-7-30(8-6-28)42(50)51/h5-10,12-17,24,37-39,52H,11,18-21,23,25-27H2,1-3H3,(H,50,51)/t37-,38+,39-,43-,44-/m0/s1
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InChIKey
HDSCFVIRPIBCNU-GZKQBEFDSA-N
Physicochemical Property
logP
8.4708
Rotatable Bonds
8
Heavy Atom Count
52
Polar Areas
98.15
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44427110
ChEMBL ID
CHEMBL388018
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000773 HepTAT Homo sapiens (Human)  1
1
Ki = 33 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.9 nM