General Information of the Compound
Compound ID
CP0050220
Compound Name
(S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoylamino)-methyl]-3-{1-[(S)-1-carboxy-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-cyclopentyl}-propionic acid
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Synonyms
(3R)-3-[[(2S)-6-amino-2-(methanesulfonamido)hexanoyl]amino]-4-[1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]cyclopentyl]butanoic acid
AC1L2YMI
C26H40N4O9S
LS-172743
SCHEMBL49065
Sampatrilat
UK 81252
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Structure
Formula
C26H40N4O9S
Molecular Weight
584.692
Canonical SMILES
CS(=O)(=O)N[C@@H](CCCCN)C(=O)NC[C@H](CC1(CCCC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)C(O)=O
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InChI
InChI=1S/C26H40N4O9S/c1-40(38,39)30-20(6-2-5-13-27)22(32)28-16-18(23(33)34)15-26(11-3-4-12-26)25(37)29-21(24(35)36)14-17-7-9-19(31)10-8-17/h7-10,18,20-21,30-31H,2-6,11-16,27H2,1H3,(H,28,32)(H,29,37)(H,33,34)(H,35,36)/t18-,20-,21-/m0/s1
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InChIKey
LPUDGHQMOAHMMF-JBACZVJFSA-N
Physicochemical Property
logP
0.3184
Rotatable Bonds
17
Heavy Atom Count
40
Polar Areas
225.22
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
8
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 6324648
SID: 14764586
ChEMBL ID
CHEMBL42583
Clinical Information about the Compound
Drug 1 ( Sampatrilat )
Drug Name Sampatrilat
Indication
Hypotension
Phase 2
Target(s)
Neutral endopeptidase (MME)
Modulator