General Information of the Compound
Compound ID
CP0046882
Compound Name
14-[[methyl(pyrazin-2-ylmethyl)sulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
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Structure
Formula
C24H21N7O3S
Molecular Weight
487.545
Canonical SMILES
CN(Cc1cnccn1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
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InChI
InChI=1S/C24H21N7O3S/c1-30-14-18(12-28-30)17-9-22-23(27-11-17)6-4-16-3-5-19(10-21(16)24(22)32)29-35(33,34)31(2)15-20-13-25-7-8-26-20/h3-14,29H,15H2,1-2H3
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InChIKey
GCIOMFVBXHMGAC-UHFFFAOYSA-N
Physicochemical Property
logP
2.7274
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
122.97
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53310829
SID: 124770279
ChEMBL ID
CHEMBL1802909
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01201, Hepatocyte growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000282 GTL-16 Homo sapiens (Human)  1
1
IC50 = 75 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2 nM