General Information of the Compound
Compound ID
CP0046612
Compound Name
CHEBI:31687
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Synonyms
2,5-Cyclohexadiene-1,4-dione, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-
2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
58186-27-9
6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
AK161748
BRN 2001459
CHEBI:31687
CV 2619
CV-2619
HB6PN45W4J
Idebenona
Idebenona [Spanish]
Idebenone
Idebenone [INN:JAN]
Idebenonum
Idebenonum [Latin]
JGPMMRGNQUBGND-UHFFFAOYSA-N
NCGC00160514-01
UNII-HB6PN45W4J
idebenone
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Structure
Formula
C19H30O5
Molecular Weight
338.444
Canonical SMILES
COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O
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InChI
InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
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InChIKey
JGPMMRGNQUBGND-UHFFFAOYSA-N
CAS
58186-27-9
Physicochemical Property
logP
3.4623
Rotatable Bonds
12
Heavy Atom Count
24
Polar Areas
72.83
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3686
SID: 12012810
ChEMBL ID
CHEMBL252556
DrugBank ID
DB09081
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01049, Cytochrome P450 2C19
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
Protein ID: PT00905, Cytochrome P450 2C9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00817, Cytochrome P450 2D6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00986, Cytochrome P450 3A4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4 Trichoplusia ni (Cabbage looper)  1
1
IC50 = 7000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Idebenone )
Drug Name Idebenone
Company Santhera Pharmaceuticals
Indication
Cognitive impairment
Approved
Friedreich's ataxia
Approved