General Information of the Compound
| Compound ID |
CP0035016
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| Compound Name |
1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea
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| Synonyms |
KRN-633
KRN633
KRN633, KRN-633, KRN 633
N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-N′-propylurea
VEGF Receptor Tyrosine Kinase Inhibitor III, KRN633
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| Structure |
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| Formula |
C20H21ClN4O4
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| Molecular Weight |
416.865
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| Canonical SMILES |
CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl
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| InChI |
InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
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| InChIKey |
VPBYZLCHOKSGRX-UHFFFAOYSA-N
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| CAS |
286370-15-8
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Clinical Information about the Compound