General Information of the Compound
Compound ID
CP0034892
Compound Name
(4aS)-6-(benzenesulfonyl)-1-(4-fluorophenyl)-4a-(pyrrolidin-1-ylmethyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
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Structure
Formula
C27H29FN4O2S
Molecular Weight
492.62
Canonical SMILES
Fc1ccc(cc1)-n1ncc2C[C@]3(CN4CCCC4)CN(CCC3=Cc12)S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C27H29FN4O2S/c28-23-8-10-24(11-9-23)32-26-16-22-12-15-31(35(33,34)25-6-2-1-3-7-25)20-27(22,17-21(26)18-29-32)19-30-13-4-5-14-30/h1-3,6-11,16,18H,4-5,12-15,17,19-20H2/t27-/m0/s1
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InChIKey
JUBJYIBDDUCCTO-MHZLTWQESA-N
Physicochemical Property
logP
4.1277
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
58.44
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44454903
ChEMBL ID
CHEMBL256894
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000229 SW1353 Homo sapiens (Human)  1
1
Ki = 4.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.5 nM